ABSTRACT

Schizophrenia is a highly disabling disease responsible for the loss of social contacts of the affected person. Quetiapine fumarate, a drug of choice, is available only as tablets and extended release tablets and suffers from the drawback of poor oral bioavailability (9%). Hence In the present study, the main objective is to improve bioavailability of Quetiapine fumarate by formulation into microemulsion. The Quetiapine fumarate micro emulsion was formulated by phase titration method using mixture of oleic acid as oil phase, tween-80 as surfactant, isopropyl alcohol as co-surfactant. Optimized ratio of tween 80: isopropyl alcohol was selected after developing pseudoternary phase diagrams for different ratio and microemulsions were prepared. The optimized formulation was evaluated for drop dilution test, dye solubility test, emulsifying time, pH, viscosity, drug content, diffusion study, stability studies. FTIR analyses showed no significant interaction between pure Quetiapine fumarate with excipients. Emulsifying time of prepared microemulsion ranged from 27 to 38 seconds and drug content of prepared microemulsion ranged from 95.45 to 97.70 %. The % drug releases for formulations F1, F2, F3, F4 and F5 at the end of 7hr were found to be 93.454, 88.324, 79.625, 65.463, and 52.987 % respectively. The formulation containing oil and Smix in the ratio 9:1 (F1) was considered as an optimized formulation with lowest emulsifying time and highest drug release at the end of 7hr was found to be 27 second and 93.45 % respectively. Keywords: Quetiapine fumarate, Oleic acid, Tween-80, Isopropyl alcohol
Publication date: 01/09/2023

https://ijbpas.com/pdf/2023/September/MS_IJBPAS_2023_7330.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.9.7330