ABSTRACT

The present project proposes to provide an eco-friendly UV spectrophotometric technique for the determination of Pirfenidone in pharmaceutical tablets, a multivariate calibration method is used. The multivariate calibration method measures the sample absorbance at various wavelengths for more precise measurements. The UV spectrophotometric method was created, and method validation was completed. All validation parameters complied with ICH standards. The estimation of Pirfenidone can be done using the suggested multivariate calibration technique method. Multivariate calibration technique utilizes the linear regression equations to correlate the relationship between concentration and amplitude at five different wavelengths, the multivariate calibration technique increases the correlation and reduces instrumental variations. Pirfenidone showed absorption maximum at 311nm in phosphate buffer pH 7.2 as diluent. The results were treated statistically. The analytical Eco scale, Agree metrics, and Green analytical procedure index was used to assess the method's greenness scores. Keywords: Pirfenidone, Multivariate calibration technique, Pharmaceutical formulations, ICH guidelines, Validation
Publication date: 01/08/2023

https://ijbpas.com/pdf/2023/August/MS_IJBPAS_2023_7358.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.8.7358