ABSTRACT

The present work aims to develop a eco-friendly UV spectrophotometric method using a multivariate calibration technique for the estimation of Acitretin in pharmaceutical capsules. For more accurate measurements, the multivariate calibration approach measures the sample absorbance at different wavelengths. The UV spectrophotometric method was developed and method validation was performed. All the validation parameters comply with ICH norms. The proposed Multivariate Calibration technique can be applied to the estimation of Acitretin. The results were treated statistically. The analytical Eco scale, Agree metrics, and Green analytical procedure index was used to assess the method's greenness scores. Keywords: Acitretin, Multivariate calibration technique, Pharmaceutical formulations, ICH guidelines, Validation
Publication date: 01/08/2023

https://ijbpas.com/pdf/2023/August/MS_IJBPAS_2023_7357.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2023/12.8.7357