ABSTRACT

Xanthium strumarium (Asteraceae) fruits have been traditionally used in the management of asthma and the current study was undertaken to scientifically validate the benefits of plant as an antihistaminic agent using the suitable animal model. The agents with antihistaminic properties are known to be good antiasthmatic agents; hence, in the current research work, the antihistaminic activity of anhydroalcoholic extract of Xanthium strumarium fruits (at a dose of 100 mg/kg, i.p) was evaluated using haloperidol- induced catalepsy and clonidine-induced catalepsy in laboratory rats. The results showed that, the hydroalcoholic extract inhibits the catalepsy induced by the clonidine but no remarkable effect was observed on the catalepsy induced by haloperidol. This strongly suggests that, the inhibition is mediated through an antihistaminic action and there is no role of dopamine. Hence, in the present study, it is concluded that, the hydroalcoholic extract has significant antihistaminic activity. The polar constituents in the hydroalcoholic extract of fruits of Xanthium strumarium may be responsible for the antihistaminic effects and therefore, the hydroalcoholicfruits extract can be a better remedy as an antihistaminic agent. Keywords: Xanthium strumarium, Catalepsy, Asthma, Antihistaminic effects
Publication date: 01/08/2023

https://ijbpas.com/pdf/2023/August/MS_IJBPAS_2023_7343.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.8.7343