ABSTRACT

The present work proposes to provide a UV spectrophotometric technique for the determination of solifenacin succinate in pharmaceutical tablets, a multivariate calibration method is used. The multivariate calibration method measures the sample absorbance at various wavelengths for more precise measurements. The UV spectrophotometric method was created, and method validation was completed. According to the obtained test findings for the current method, there was no statistically significant difference and all validation parameters complied with ICH standards. The current study targets on the development of UV spectrophotometric method in second derivative mode for solifenacin succinate in bulk and pharmaceutical formulation employing multivariate calibration technique. Multivariate calibration technique utilizes the linear regression equations to correlate the relationship between concentration and amplitude at five different wavelengths, the multivariate calibration technique increases the correlation and reduces instrumental variations. solifenacin succinate showed absorption amplitude at 228nm in ethanol as solvent. The results were treated statistically. The analytical Eco scale, Agree metrics, and Green analytical procedure index was used to assess the method's greenness scores. Keywords: Solifenacin succinate, Second derivative mode, Multivariate calibration technique, Pharmaceutical formulations, ICH guidelines, Validation
Publication date: 01/08/2023

https://ijbpas.com/pdf/2023/August/MS_IJBPAS_2023_7340.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.8.7340