ABSTRACT

The study aims to utilize and evaluate a modest, precise, and accurate UV spectrophotometric technique for quantifying Beclomethasone Dipropionate in pharmaceutical dosage form utilizing multivariate calibration technique. The multivariate calibration methodology depends on linear regression equations and the relationships between concentration and absorbance at five distinct wavelengths. The results were treated statistically and confirmed as per the ICH guidelines. The developed method was accurate, precise, reproducible, linear within the range of 6 – 18 ?g/mL. This statistical method yields the best results by minimizing variations caused by instrumental or experimental settings. Under optimum conditions, the applied statistical method provides great resolving power, sensitivity, velocity and is inexpensive for quantification, quality management, and recurrent analysis of Beclomethasone Dipropionate in pharmaceutical dosage forms. Keywords: Beclomethasone Dipropionate, Asthma, UV Spectrophotometer, Multivariate calibration
Publication date: 01/08/2023

https://ijbpas.com/pdf/2023/August/MS_IJBPAS_2023_7336.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.8.7336