ABSTRACT

In recent times more focus is to formulate an innovative drug delivery system for poorly water-soluble drugs to increase the bioavailability of the drug as compared to conventional dosage forms. The present work aimed to develop, optimize and characterize a Liposomal drug delivery system of telmisartan for the treatment of hypertension. Liposomes were developed by using the thin film Hydration technique using the Rota evaporator. Preliminary screening of lipids was done to select the lipid for formulation. Optimization of Liposomal formulation was done by Box Behnken design (BBD) by using design expert 12 version software. Independent factors selected were the amount of lipid, amount of cholesterol & sonication time and dependent variables were entrapment efficiency and particle size. From the result of the preliminary study Phospholipon, 90 H was selected. Batch S7 showed a particle size of 315.7±0.10 and Maximum entrapment efficiency of 80.14±0.02 %. The optimized formulation showed the entrapment efficiency & particle size of the optimized batch (L2) were 260.60 ± 0.1 and 70.4 ± 0.017 respectively. In-vitro drug release of 12 hrs of the optimized batch was found to be 98.57 ± 0.02. Transmission Electron microscopy (TEM) showed that the drug was satisfactorily entrapped and liposomes were spherical. As per ICH guidelines stability studies were conducted and found to be stable. It was concluded that telmisartan Liposomes have all the required qualities of a vesicular drug delivery system. Throughout, 15 batches L2 was found to be most appropriate with low particle size and higher entrapment efficiency. Also found stable in the stability study. Keywords: Telmisartan, Liposomes, Thin Film hydration method, Box Behnken design
Publication date: 01/08/2023

https://ijbpas.com/pdf/2023/August/MS_IJBPAS_2023_7328.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2023/12.8.7328