ABSTRACT

Medicinal plants are playing an imperative role in the therapy for treating various chronic ailments including arthritis. Using In-vivo arthritis models, the current study was started to assess the anti-arthritic effects of ethanol extract and aqueous extracts of Bauhinia acuminata Linn. In-vivo anti-arthritic activity of ethanolic and aqueous extract at a dose of 200 mg/kg and 400 mg/kg respectively was assessed using formaldehyde- induced arthritis on 0th day, 7th day, 14th day, 21st day and 28th day.Bauhinia acuminata Linn produced significant (**p<0.01) dose dependent inhibition of paw volume edema and markedly improved hematology profile. In formaldehyde-induced arthritis models, the ethanolic extract of leaves of Bauhinia acuminata Linn at 400 mg /kg significantly (**p<0.01) reduced paw volume edema by 70.24%on 28thday. Whereas ethanolic extract of leaves of Bauhinia acuminata Linn 200 mg/kg, b.w., p.o.,) appears to show significant activity (*p<0.05) on day 28th with 61.157% inhibition. The aqueous extracts of leaves of Bauhinia acuminata Linn at 400 mg/kg appears to show significant activity (*p<0.05) on day 28th reduced paw volume edema by 58.677%. Whereas aqueous extract of leaves of Bauhinia acuminata Linn 200 mg/kg, b.w., p.o.,) appears to show significant activity (*p<0.05) on day 28th with 54.54% inhibition.It could be concluded that Bauhinia acuminata Linn holds anti-arthritic potential, supporting its traditional use in treatment of rheumatoid arthritis. Keywords: Bauhinia acuminata Linn, Anti-Arthritic Activity, Medicinal plants
Publication date: 01/07/2023

https://ijbpas.com/pdf/2023/July/MS_IJBPAS_2023_7323.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2023/12.7.7323