A SYSTEMATIC REVIEW AND META-ANALYSIS OF ?2-AGONIST MEDICATIONS TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD): NEED FOR COMPREHENSIVE ASSESSMENT AND PHARMACOVIGILANCE Authors: Vikash P , KOUSHIK Y AND RAMA RAO N
ABSTRACT
Chronic Obstructive Pulmonary Disease (COPD) is becoming the second leading cause of death in the
world where 80% of deaths are reported from low and middle-income countries. COPD is a chronic
disease of high prevalence in younger as well as older people majorly due to smoking, air pollution,
long-term exposure to harmful gases, and other comorbidities. COPD with other comorbidities are
frequent among patients of internal medicine part, and usually, these patients are more drug
dependents. Certain COPD medications, such as ?2-agonists, antimuscarinic compounds,
methylxanthines, and other combinational medicines, are considered high risk due to their
involvement in ended with adverse events. Above all ?2-agonists are the first choice of medication to
treat COPD. However, the efficacy of the drug is the link between the potential benefits and risks.
Considering the side effects of COPD patients, it is necessary to develop appropriate drug
management. Drug management is a complicated process that involves specific knowledge,
techniques, and methodologies to identify risks and mitigate them with a proper action plan. Timely
reporting of adverse drug reactions is required to minimize the chances of risk to patients and the healthcare system. So, Health care professionals need to bring new practices for pharmacovigilance in
COPD.
Keywords: Beta2-agonists, Chronic Obstructive Pulmonary Disease (COPD), Adverse Drug
Reactions (ADR), Pharmacovigilance, Nasal Patches Publication date: 01/07/2023 https://ijbpas.com/pdf/2023/July/MS_IJBPAS_2023_7322.pdfDownload PDFhttps://doi.org/10.31032/IJBPAS/2023/12.7.7322