ABSTRACT

Introduction: An adverse drug reaction (ADR) is defined by the World Health Organization (WHO) as any noxious, unintended, or undesired effect of a drug that occurs at doses used in humans for prophylaxis, diagnosis, or therapy. To evaluate the probability of true ADRs from suspected ADRs, Naranjo et al. has proposed a tool and has been widely used as Naranjo Algorithm. The main aims of this study are to assess the pattern of ADRs, causality, offending drugs, monitoring and documenting suspected ADR(s) and to prevent the occurrence. Methodology: A retrospective study was carried over a period of 6 months. The reactions were categorized based on patient demographics and ADR characteristics (the type of ADR, causality, severity, system affected, outcome and management). Data were demonstrated in the form of frequency and tables. Results: Causality assessment of suspected ADRs using Naranjo's scale showed that 16.66% of them were probable and 83.33 % categorized as possible. The severity of reactions was reported as 46.66% each in case of mild and moderate. 6.66% considered as severe. Conclusion: This study concluded that the reporting of ADRs is fairly good in this hospital. Although the ADRs in the present study were serious and preventable. Monitoring and management of such ADRs through therapeutic interventions beneficial for patient care. Keywords: Adverse drug reaction, Causality, Naranjo scale, Monitoring, Severity
Publication date: 01/07/2023

https://ijbpas.com/pdf/2023/July/MS_IJBPAS_2023_7302.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.7.7302