ABSTRACT

Breast cancer has become an overburdened public health issue for Women in both developed and developing countries. Among many risk factors, presence of excess estrogen, estrogen receptor-? and tumour necrosis factor -? are found to be the major cause of breast cancer. This study aimed to qualitatively analyse and screen the phytoconstituents in ethanolic extract of Micrococcus mercurialis stem by GC-MS analysis and binding effect of two phytocompounds phytol and 4H-pyran-4-one, 2,3-dihydro- 3,5-dihydroxy-6-methyl against estrogen receptor-? (ESR-?) and TNF-? by in silico docking method to identify their anticancer potential. Ethanolic extract of Micrococcus mercurialis stem revealed the presence of 26 phytocompounds. Among the two selected phytocompounds, 4H-pyran-4-one, 2,3- dihydro- 3,5-dihydroxy-6-methyl exhibited better binding potential towards both estrogen receptor-? (ESR-?) (- 6.3 Kcal/Mol) and TNF-? (- 5.29 Kcal/Mol) when compared with phytol. The results warrant further in-vitro and in-vivo research to explore the anticancer and anti-inflammatory potential of Micrococcus mercurialis. Key words: Micrococcus mercurialis, Breast cancer, GC-MS analysis, Estrogen receptor-? (ESR-?) and TNF-?, 4H-pyran-4-one, 2,3-dihydro- 3,5-dihydroxy-6-methyl, in silico docking
Publication date: 01/07/2023

https://ijbpas.com/pdf/2023/July/MS_IJBPAS_2023_7298.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2023/12.7.7298