ABSTRACT

Benzothiazole is a heterocyclic organo-sulfur moiety which is weakly basic. Benzothiazole pharmacophore containing a benzene ring that is combined with a five membered thiazole ring at position 4 and 5. Benzothiazole and its derivatives demonstrate a huge variety of pharmacological effects such as anticancer, antimicrobial, antimalarial, antituberculosis, antidiabetic, anthelmintic, antioxidant, anti-inflammatory, anti-glutamate, antiparkinsonism, anticonvulsant, muscle relaxant activity, neuroprotective, inhibitors of numerous enzymes. In this review, we discussed benzothiazole chemistry, recent synthesis procedures and pharmacological activities of commonly developed benzothiazole derivatives in brief, as well as numerous structural modifications performed on the benzothiazole ring and privileged specificities communicated in their biological responses. Keywords: Benzothiazole; Antimalarial; Pharmacophore; Pharmacological activities
Publication date: 01/07/2023

https://ijbpas.com/pdf/2023/July/MS_IJBPAS_2023_7275.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.7.7275