It is postulated that, elevated CRP levels independently predict the risk of future stroke and
transient ischemic attack in the elderly. This study was intended to find association of hs-CRP (>3 mg/L)
with acute ischemic stroke. This one year prospective study was done in under the Department of
Neurology, Ankineedu Stroke Center, Lalitha Super Specialities Hospital, Guntur, Andhra Pradesh on
100 patients presenting with acute ischemic brain stroke from 1st February, 2017 to 31st January 2019.
Most of the patients presentated with Hemiparesis (80%) followed by Dysarthria (61%). Majority of the
patients presented with hypertension as risk factor (81%) followed by ischemic heart disease (72%). The
GCS score between 3 to 8 on day one was noted among 56% of the patients while on day 7 and day 30,
GCS was > 8 in 70% and 77% of the patients. hs-CRP levels were > 3 on day one in majority of the
patients (88%). On day seven, hs-CRP levels were > 3 in 62% of the patients and on day 30, 58% of the
patients has hs-CRP levels of < 3. NIHS score of > 15 was noted on day 1 in 55% of the patients while 7,
39% of the patients had NIHS score of < 5 while on day 30 and 59% of the patients had NIHS score of <
5. The mean hs-CRP levels were significantly high in patients with severe NIHS scores (>15) compared
to patients with moderate (5 to 15) and mild (< 5) NIHS scores on day one (14.14 ± 4.51; p<0.001), day
seven (11.95 ±2.31; p<0.001), and day 30 (9.49 ± 2.45; p<0.001). Furthermore, mean Age, mean SBP,mean DBP, mean Neutrophils, mean ESR, mean blood urea, mean serum creatinine, mean total
cholesterol, mean GCS and mean NIHS on day 1, 7 and 30 differed significantly (p<0.050).
Keywords: High sensitive C-reactive protein, National Institute of Health Stroke Scale
(NIHSS), Glasgow Coma Scale (GCS), Acute Ischemic Stroke
Publication date: 01/07/2023
https://ijbpas.com/pdf/2023/July/MS_IJBPAS_2023_7239.pdf
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https://doi.org/10.31032/IJBPAS/2023/12.7.7239
