ABSTRACT

Ayurveda has gained a lot of attention by its effectiveness and popularity. This medical system originated centuries ago with medicines prepared as per needs of the individual cases. In the present era, where medicines are manufactured on a larger scale, it requires standardisation in order to keep up the quality and efficacy. This study is aimed to standardize a compound Ayurveda formulation intended for managing the clinical symptoms of hypothyroidism by its organoleptic evaluation, physicochemical and chromatographic analysis. The physico-chemical analysis of the tablets was performed as per API standards. The formulation was subjected to TLC-HPTLC fingerprinting. All physicochemical parameters like uniformity of weight, disintegration time, friability, hardness were done as per API protocol and hence the results obtained can be used for standardisation of this particular Gulika. TLC of compound formulation was developed in Toluene : chloroform : methanol (8:3:1) solvent system resulted in maximum compound separation and observed for significant spots. HPTLC analysis showed presence of various compounds whose structural identification could not be confirmed with matching Rf of standard compounds. Key words: Hypothyroidism, Ayurveda, TLC-HPTLC fingerprinting, Standardisation
Publication date: 01/07/2023

https://ijbpas.com/pdf/2023/July/MS_IJBPAS_2023_7235.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.7.7235