ABSTRACT

Nanoparticles are considered as one of the novel promising carrier systems. Nano technology deals with fabrication, manipulation as well as use of materials in nanometres range. The ability to penetrate cells and cross blood–brain barrier is a distinct characteristic of nanoparticles and they are easily destroyed. Nanoparticles can be fabricated from biodegradable or non-biodegradable materials. In the present review, various types of nanoparticles and their characteristics, formulation and fabrication of different nanoparticles, characterization of nanoparticles, applications, challenges to be overcome with the use of nanomedicines and future perspectives were elaborated. Polymeric nanoparticles have numerous applications; yet, there are challenges related to the synthesis of polymeric nanoparticles which are required to be addressed before such formulations can be completely used & adapted into applications. Research in the field of nanoparticulate DDS have witnessed remarkable growth and progresses. However, only limited nano drug formulations developed by both academia as well as biopharmaceutical industry have been granted approval for clinical use. Similarly, very few reports are available related to scale-up production of polymeric nanoparticles. Improvement and changes in the physicochemical characteristics provide a new dimension to more effective, beneficial and safer nanoparticulate DDS. Nanoparticulate systems have been emerged as a promising platform to achieve targeted or site-specific drug delivery. Keywords: Nanoparticles, fabrication, characterization, applications
Publication date: 01/07/2023

https://ijbpas.com/pdf/2023/July/MS_IJBPAS_2023_7108.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.7.7108