ABSTRACT

A series of novel {3-[2-(5-chloro-1H-benzimidazol-2-yl)-2-oxoethyl] phenyl} acetic acid and its derivatives were synthesized by treating various 1-(5-chloro-1H-benzimidazol-2-yl)-2-(3- hydroxyphenyl) ethanone with hydroxy acetic acid heat/ reflux this reaction for 4 hrs. The title compounds and its derivatives were investigated for in vitro antibacterial properties against some human pathogenic microorganisms by employing the agar dilution method using Gentamycin as standard drugs. All title compounds showed activity against some strains of microorganism. Structural activity relationship studies reveal that compounds possessing an electron-withdrawing group exhibit better activity than the compounds containing electron-donating groups. Based on the results obtained, When compared to common medicines like Gentamycin, the compounds N- ({3-[2-(5-chloro-1H-benzimidazol-2-yl)-2-oxoethyl]phenyl}acetyl)benzamide (AI);2-{3-[2-(5- chloro-1H-benzimidazol-2-yl)-2-oxoethyl]phenyl}-N-phenylacetamide (AJ); 2-{3-[2-(5-chloro- 1H-benzimidazol-2-yl)-2-oxoethyl]phenyl}-N-(2-nitrophenyl)acetamide (AK); 2-{3-[2-(5- chloro-1H-benzimidazol-2-yl)-2-oxoethyl]phenyl}-N-(3-nitrophenyl) acetamide (AL) gives potent anti-bacterial activity. A group of heterocyclic, aromatic compounds, is the fusion of a six-membered benzene ring with a five-membered imidazole moiety. The use of molecules with benzimidazole motifs in biological and medical research has shown promise. Formic acid, Acetyl chloride, Benzene-1,2-diol, Glycolic Acid, Benzoyl chloride, Methyl chloride, Ethyl chloride, Benzamide, and other chemicals were utilized in this study. The methods employed were TLC, IR spectra, 1H-NMR, and MS. The agar dilution method was used to conduct the pharmacological screening for antibacterial activity. Keywords: Antibacterial, 5-chloro-1H-benzimidazole; hydroxy acetic acid; Glycolic Acid, Benzoyl chloride
Publication date: 15/06/2023

https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_JUNE_SPCL_1065.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.6.1065