ABSTRACT

Diabetes mellitus is a chronic metabolic disorder that affects millions of people worldwide. Traditional treatments for diabetes, such as insulin therapy and oral hypoglycemic agents, have various limitations and side effects. Natural flavonoids, which are widely found in plants and have demonstrated antioxidant, anti-inflammatory, and hypoglycemic properties, are promising candidates for the treatment of diabetes. This review article focuses on the natural flavonoids commonly used for the treatment of diabetes mellitus. It covers the chemical structures, sources, and mechanisms of action of these flavonoids, as well as their potential therapeutic benefits. The article highlights the antidiabetic effects of flavonoids on insulin secretion, glucose uptake, and insulin signalling pathways. Several studies have shown that natural flavonoids can effectively lower blood glucose levels, improve insulin sensitivity, and prevent diabetic complications. The article also discusses the safety profile of these compounds, including their potential toxicity and interactions with other medications. Overall, the review suggests that natural flavonoids hold great potential as alternative or adjunctive therapies for the treatment of diabetes mellitus. However, further research is needed to better understand the optimal doses, formulations, and modes of administration of these compounds, as well as their long-term safety and efficacy. Keywords: Flavonoids; Diabetes Mellitus; Hypoglycemic; Insulin Sensitivity; Natural Compounds
Publication date: 15/06/2023

https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_JUNE_SPCL_1040.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.6.1040