ABSTRACT

The present study aims to determine the phytoconstituents and anti-oxidant content, radical scavenging potential, in vitro anti-inflammatory and antimicrobial potential of Cecropia peltata leaves extracts. The content of phenol, flavonoid, tannin and alkaloids were measured by in vitro methods. Scavenging ability of Cecropia peltata leaf extracts were assessed against DPPH and hydroxyl radical. The metal chelating potential was also determined. Anti-inflammatory potential of the extracts were determined by albumin denaturation assay. Anti-microbial potential of the ethyl acetate and ethanol extract of Cecropia peltata leaves against Pseudomonas aeruginosa, Pseudomonas vulgaris, Escherichia coli, Bacillus sp., and Candida albicans were determined. The results shows that ethyl acetate extract of Cecropia peltata leaves possess appreciable amount of phenols, alkaloids and flavonoids with a positive correlation towards free radical scavenging potential of DPPH, hydroxyl radical and metal chelating property. The IC50 value of ethyl acetate extract and ethanol extract of Cecropia peltata leaves were 494 ?g /ml and 493 ?g/ml and 542 ?g /ml for standard Diclofenac. Among the two, ethyl acetate extract of Cecropia peltata leaves inhibited the tested pathogens very effectively than ethanol extract. Thus, the presence of potent antioxidants and antimicrobial property in Cecropia peltata leaves will help in drug development against as oxidants and antimicrobial agents. Keywords: Cecropia peltata, Anti-oxidant, Antimicrobial, Anti-inflammatory
Publication date: 15/06/2023

https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_JUNE_SPCL_1038.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2023/12.6.1038