Nephrotoxicity is one of the most common kidney problems which is increasing gradually due to
the increase in usage of several potent therapeutic drugs like aminoglycosides, antibiotics,
chemotherapeutic agents, NSAIDs, and due to some systemic diseases, such as hypertension,
hypercholesterolemia, diabetes mellitus, etc. The usage of these drugs and systemic diseases are
inevitable, so nephroprotection may play an important role in this area. Current therapies for
nephrotoxicity include peritoneal dialysis, hemodialysis, and kidney transplantation, which are
costly regimens linked to high morbidity. Therefore, it is beneficial to administer nephroprotective
drugs along with nephrotoxic drugs to reduce their toxicity without affecting the therapeutic
efficacy. There are synthetic nephroprotective drugs available, but the use of natural
nephroprotective agents is safer as they act without adversely influencing the body. Therefore, it
was a literary search for a formulation in Ayurveda that has nephroprotective action. Patoladi
Gana is a formulation from Ashtaang Hridya which is a combination of Patol, Kutaki, Chandan,
Murva, Guduchi, and Patha. Various research studies show the efficacy of these contents in
Mutravaha Strotas Dushti Vikar i.e., nephrotoxicity. So, by studying literature from both Ayurveda & Contemporary sciences, the present literary study was an attempt to establish nephroprotective
potential and to highlight the mechanism of nephroprotection of this ayurvedic formulation i.e.,
Patoladi Gana.
Keywords: Nephrotoxicity, Nephroprotective, Patoladi Gana, Mutravaha Strotas Dushti, Vishaghna
Publication date: 15/06/2023
https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_JUNE_SPCL_1021.pdf
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https://doi.org/10.31032/IJBPAS/2023/12.6.1021
