ABSTRACT

Panax ginseng, one of the most well-known herbal remedies. Ginsenosides are P. ginseng's major active components, which were demonstrated to have a wide range of medicinal effects. Many studies indicate that ginsenosides provide a range of activities in both pathologic and physiological conditions related to cardiovascular disease. Albino Wister rats (150-200 gm) were sacrificed and the heart was removed along with the aorta as rapidly as possible and the tissue was plunged into an ice-cold Krebs Henseleit solution. The heart had blood flow at a constant pressure of 90 cm of water with Krebs Henseleit solution, maintained at 37ºC and Ph 7.4. The test drug was injected (0.1 ml) and the heart rate and the contractions of the heart for a minute were recorded. The droplet was shown to diminish as the dose of Ach was raised when it was administered at various doses of 0.1, 0.2, 0.4, and 0.8 ml from a 100 g/ml stock solution. 72, 66, 51, and 24 drops of the appropriate dosages of Ach were obtained, showing the typical bradycardia and hyperpolarization of the SA nodal cell of Ach. After adding 0.1, 0.2, 0.4, and 0.8 ml of a 1 mg/ml stock solution to the heart and counting the droplets, the appropriate doses of 82, 86, 90, and 89 droplets were produced. The result of this experiment reveals, ginseng is having cardio stimulant activity within a limit which may act as a cardio tonic also, but after confirming the same experiments on hypodynamic heart. Keywords: Panax ginseng, cardiovascular disease (CVD), Hydroalcoholic extract, Heart rate
Publication date: 15/06/2023

https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_JUNE_SPCL_1018.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.6.1018