Micronutrient, macronutrient, and vitamin deficiencies can have a negative impact on both mental and
physical health, thus it's important to fix them. There will be a further benefit to supplementing
nutritional supplements with permitted herbs. Since there is a lack of reliable preclinical evidence about
the safety and efficacy of multivitamin-mineral-herbal (MMH) tablets for depression, stress, anxiety,
and physical performance, the present study intended out to address that gap. Acute toxicity effect was
investigated to ensure the safety of tablets. The open-field test and the elevated plus maze were used to
evaluate antianxiety property, while the immobility stress test was performed to measure antistress
activity in rats. The study showed that administration of MMH in tablet form was safe up to 2000 mg/kg
BW, and that doing so had a notable effect on both physical and mental health. The animal had a
significant increase in body weight from week to week. Affirming that health is better after
pretreatment. Compared to the control group, the experimental rats swam for significantly longer
periods of time. Both the 200 mg/kg and 400 mg/kg MMH tablet groups showed significantly higher
locomotor activity than the control group of rats (p<0.001), with a mean increase of 271.17±65.98 and
352±90.77, respectively. Time spent in the centre, time spent in the open arm, number of open arm
entries all increased significantly, as did the total time spent in the open arm throughout the elevated
plus maze test. Rats that were pretreated with MMH showed a substantial reduction in depressive
symptoms (p<0.001). In an open field test, rats given the maximal dose of the tablet preparation spent
less time in the corner block and more time in the centre block, and there was no significant rearing or
other negative effects. The number of ulcers, ulcer scores, gastrointestinal volume, and percentage of ulcer inhibition were all significantly reduced across all dosages of tablet formulations, suggesting
considerable antistress effect. We draw the conclusion from these findings that, at an adequate dose,
MMH pills are safe, improve physical performance, and assist overcome depression, stress, and anxiety.
Keywords: Animal study, Lotomotor activity, Overall health, Mental health, Physical health,
Physical endurance
Publication date: 15/06/2023
https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_JUNE_SPCL_1014.pdf
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https://doi.org/10.31032/IJBPAS/2023/12.6.1014
