ABSTRACT

Aim: Alternanthera philoxeroides (Amaranthaceae) weed has a great importance in Ethnobotany among different community in Assam and other regions of India. The main focus of present study was to evaluate synergistic in-vivo analgesic and anti-inflammatory activity of Alternanthera philoxeroides leaves and roots based on the traditional practice by the villages of lower Assam, India. Methods: Equal portion of powdered plant materials were extracted successively using petroleum ether (40-60oC), Chloroform, Ethyl acetate, Acetone, Methanol and Hydro-alcohol (9:1) followed by their phytochemical screening. Synergistic anti-inflammatory activity was evaluated by carrageenan and egg albumin induced paw edema while synergistic analgesic activity was evaluated by acetic acid induced writhing and Eddy’s hot plate method for different doses of methanolic extract. Results: Results revealed that methanol extract contained most of the phyto-constituents. The 500 mg/kg bodyweight dose of extract showed very potent anti-inflammatory activity (% inhibition at 240minute: standard 57.9%, extract 42.84%) as well as analgesic activity (% inhibition in acetic acid induced method: standard 72.43%, extract 53.86%; mean reaction time at 120 minute in Eddy’s hot plate method: Standard 13.09±0.08, extract 3.67±0.04). Conclusions: This study revealed potentiality of the plant materials with considerable analgesic and anti-inflammatory activities which have a great scope of development of drugs and nutraceuticals. Keywords: Alternanthera philoxeroides, Synergistic, Anti-inflammatory activity, Analgesic activity
Publication date: 01/06/2023

https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_JUNE_SPCL_1012.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.6.1012