ABSTRACT

Background: Grangea maderaspatana has traditionally been used to treat neurological disorders. The purpose of this study was to look into the phenolic content, antioxidant activity, and acetylcholinesterase enzyme (AChE) inhibitory activities of various fractions of Grangea maderaspatana grown in local areas of kurnool. Methods: The whole plant of Grangea maderaspatana was extracted with methanol and total phenolic content was estimated by folin-catechu method. DPPH (1,1-Diphenyl-2-picrylhydrazyl) assay was used to measure antioxidant activity, while Ellman's colorimetric method was used to measure AChE inhibitory activity. Results: Our findings indicated that the methanolic fraction had the highest total phenol concentration, which is comparable to 25.21.4 mg quercetin/g of fraction. Our findings also showed that the methanolic fraction had the highest antioxidant activity and AChE inhibitory activity when compared with the standard in a dose-dependent manner. Conclusions: Our findings suggest that Grangea maderaspatana methanolic extract could be a promising source of AChEinhibitors for Alzheimer's disease. Keywords: Alzeimer,s disease, DPPH radical, IC 50, HPTLC fingerprinting
Publication date: 01/06/2023

https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_72261.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.6.7226