ABSTRACT

This research article describes simple, specific, accurate and precise Reverse Phase High Pressure Liquid Chromatographic method for the simultaneous determination of fexofenadine hydrochloride and Montelukast sodium in tablet dosage form. The chromatographic separation was achieved on 4.6 mm X 10 cm column containing packing L1 as stationary phase with a mobile phase comprising of water: methanol (35: 65) at a flow rate of 1.2mL/min, column temperature of 450C and UV detection at 254 nm. The retention time of Fexofenadine and Montelukast Sodium hydrochloride were 6.776 min and 3.776min respectively. The linearity were found to be in the range of 200-600 mg/mL and 200-600 mg/mL for Fexofenadine and Montelukast Sodium hydrochloride with correlation coefficient greater than 0.999. The proposed methods were validated as per ICH guidelines for the determination of drugs in tablet dosage form. Keywords: Fexofenadine, Montelukast, RP-HPLC, Method Development
Publication date: 01/06/2023

https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_7213.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2023/12.6.7213