ABSTRACT

Introduction: The first case of COVID 19 emerged in city of Wuhan, China in December 2019, Till August 2020 World Health Organization (WHO) reported that 24.7 million cases were reported inclusive of 830,000 deaths. Many countries have suffered a two-wave pattern of COVID cases, called first wave and the second wave. This study was aimed to compare the levels of Biochemical markers (LDH, ferritin, D-dimer and CRP) from patients infected during the first wave and the second wave in a rural tertiary care hospital Chengalpet district. Methodology: A Cross sectional study was done between June to August 2020 and June to August 202. About 299 RT-PCR positive SARS COV-2 patients serum/plasma samples were collected from first and second wave of COVID-19 The inclusion criteria were individuals with age above 18years with RT-PCR positive for SARS COV-2 and the exclusion criteria was age below 18 years. Result: The median value of LDH for second wave is 611 and the first wave 473 which lies between the (425 – 804) and (385 - 625) as its 25th percentile and 75th percentile respectively, For ferritin, median value of second wave is 402 and the first wave is 254 which lies between the (217 - 707) and (112 - 422) at its 25th percentile and 75th percentile respectively, D-Dimer has its median value as 0.56 for second wave and 0.54 for first wave. CRP has its median value as 35 for second wave and 44 for first wave which lies between the (21 – 56) and (25 - 65) as its 25th percentile and 75th percentile respectively, Thus LDH, Ferritin and D-dimer serum levels are raised in second wave and CRP raised in First wave of COVID-19. Conclusion: The D-dimer, CRP, LDH and ferritin were strongly associated with COVID-19 disease and these biomarkers have been shown to have the capacity to diagnose, predict severity and complication and have usefulness in monitoring treatment response Keywords: COVID-19, LDH, Ferritin, D-dimer, CRP
Publication date: 01/06/2023

https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_7211.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.6.7211