ABSTRACT

In the present work a simple, sensitive, accurate and reproducible ultraviolet spectrophotometric absorption correction method was developed and validated for the simultaneous estimation of Montelukast sodium and Acebrophylline in bulk and marketed tablet dosage form. Methanol was used as a solvent to prepare stock solutions. Montelukast sodium was estimated directly at 345 nm as Acebrophylline showed no interference with zero absorbance at this wavelength. Both the drugs showed absorbance at 334 nm. Thus the amount of Acebrophylline was estimated by correcting the absorbance of Montelukast sodium for interference at 334 nm. Absorptive values were used for this purpose. The method obeyed Beer’s law in the concentration range of 5-10 mcg/ ml for Acebrophylline and 100- 200 mcg/ mL for Montelukast sodium. The developed analytical method was found to be accurate and precise after its validation as per ICH guidelines. Thus, by using proposed method, simultaneous estimation of Montelukast sodium and Acebrophylline can be successfully carried out in bulk and in combination dosage form of tablet as well. Keywords: Absorption correction method, Acebrophylline, Montelukast Sodium, Simultaneous estimation
Publication date: 01/06/2023

https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_7210.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.6.7210