ABSTRACT

The aim of the study was the optimization of N-Acetyl Cysteine (NAC) loaded solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in terms of physicochemical and biopharmaceutical properties, to develop effective and stable formulations. And characterize their physicochemical properties, in-vitro drug release behaviour parameter. Homogenization technique was the preferred method of preparation for nanoparticles. FTIR, DSC, XRD study results indicated no interactions between the drug and formulative ingredients, lipid structure and undisturbed structural nature of NAC in the formulations. The morphology of the prepared distinct types of nanoparticles was found to be approximately spherical in shape and to have a rough surface, according to SEM photographs. The mean particle size of the produced nanoparticles varied between 99.23±11.21 and 159.10±15.36nm depending on the formulation. The PDI ranged from 0.157±0.21 to 0.232±0.13 in this study. The developed formulation's entrapment efficiency was in the range of 62.56±1.25-86.32±1.24%. Among the four types of nanoparticles highest amount of release percentage i.e., 95.25% was found for solid lipid nanoparticles. Finally, among the four types of NAC loaded nanoparticles no statistically significant differences between NLCs and SLNs, were found, and they are deemed promising carriers for anti-oxidant drug delivery. Keywords: NAC -N Acetylcysteine, SLN-Solid lipid nanoparticles-Nano lipid carriers, NDC- Nano drug conjugates, LPHNP-Lipid polymer hybrid nanoparticles
Publication date: 01/06/2023

https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_7197.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.6.7197