ABSTRACT

The objective of the current research was to formulate and characterize leflunomide nanosuspension using nanoprecipitation method so as to achieve faster drug dissolution. In the present investigation, an attempt was made to prepare nanosuspensions of leflunomide using nanoprecipitation method. The developed leflunomide nanosuspensions were evaluated for particle size, zeta potential, poly dispersity index, % encapsulation efficiency and in-vitro drug release. Particle size range of leflunomide nanosuspensions were noticed in the range of 921.4 to 1439.6 nm which is based on the change in drug and the excipients concentrations. Formulations of nanosuspensions exhibited negative zeta potential in the range of -11.5 to +23.2 mv and polydispersity index 0.2 to 0.3. F2 & F6 formulations showed greater % entrapment efficiency i.e., 65.5% and 68.2%. In vitro drug release profile of leflunomide nanosuspension formulations F2 & F6 exhibited up to 90.76 % and 91.04% release in 8 h. Therefore, it is concluded that nanoprecipitation method have a capability to formulated consistent and uniform-sized nanosuspensions of leflunomide. The formulated nanosuspensions exhibited increased in vitro drug release profiles which can increase the oral bioavailability of drug. Keywords: Leflunomide, nanoprecipitation, nanosuspension, % entrapment efficiency, in vitro drug release
Publication date: 01/06/2023

https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_7192.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.6.7192