ABSTRACT

The present study deals with formulation and evaluation of bilayer tablet of paracetamol and diclofenac sodium to provide control release of drug and to maintain the drug concentration. The major ingredients are paracetamol granules and diclofenac sodium granules and were prepared separately by wet granulation method. Paracetamol, PEG6000 and intergranular fraction granules were cooled and blended with microcrystalline cellulose, crosscarmellose, magnesium stearate and mixture of diclofenac sodium and HPMC K100 were granulated using water and isopropyl alcohol. The wet mass is passed through a 20# sieve and dried. The granules of optimized batch of paracetamol and diclofenac sodium were compressed to obtain bi-layer tablet. The tablets were evaluated for percentage friability, crushing strength and in-vitro drug release. Totally 3 formulations for paracetamol and 2 formulations of diclofenac were prepared and studied for their various parameters. The formulation F2 for paracetamol showed in-vitro drug release of 82% and exhibited satisfactory results in all parameters and subjected to stability studies. And the formulation D2 showed in-vitro drug release of 86.11% and exhibited satisfactory results. Thus formulation F2 for paracetamol and D2 for Diclofenac was found to be successful conventional release and modified release bi-layer tablet and can be manufactured with reproducible characteristics from batch to batch. Keywords: HPMC K100, Paracetamol, Microcrystalline Cellulose
Publication date: 01/06/2023

https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_7188.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.6.7188