ABSTRACT

Introduction: Benzimidazoles are a class of heterocyclic, aromatic compounds which share a fundamental structural characteristic of six-membered benzene fused to five-membered imidazole moiety. Molecules having benzimidazole motifs showed promising application in biological and clinical studies. Objective: Synthesis and biological activity of benzimidazole derivatives. Materials & methods: Formic acid; Acetyl Chloride; Benzene-1,2-diol; Glycolic Acid; Benzoyl Chloride; Methyl Chloride; Ethyl Chloride; Benzamide etc and method is TLC, IR spectra, 1H-NMR and MS Results & Conclusion: The pharmacological screening was done by using PTZ Induced Convulsion Method for anticonvulsant activity. The synthesize compounds were establish to be AA to AL. The compound AA, AC, AJ, AK and AL were established to be the most potent compound through compare to standard drugs phenytoin. Keywords: Benzimidazole; Glycolic Acid; Benzene-1, 2-diol; 2- Nitro Aniline, PTZ; Anti Convulsant Activity
Publication date: 01/06/2023

https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_7122.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.6.7122