ABSTRACT

Liver illnesses are a serious public health concern around the world, necessitating the development of novel chemicals to combat or prevent them. As a result, researchers have been looking for natural and/or synthetic substances that exhibit hepatoprotective properties. The identification of pharmacological effects in cellular and animal models leads to the demonstration of efficacy and safety in people, which is the ultimate step in the development of new medications. In this literature, there are a variety of models for evaluating hepatoprotective efficacy in vitro, ex vivo, and in vivo. The goal of this review is to show the most commonly used hepatotoxic agents (CCl4, acetaminophen, ethanol, d-galactosamine, t- BuOOH, rifampcin and isoniazid ,thioacetamide) and biochemical parameters for assessing liver damage in the various models and there were also some plant extracts used. Keywords Liver illnesses, novel chemicals, hepatoprotective properties, pharmacological effects, biochemical parameters
Publication date: 01/06/2023

https://ijbpas.com/pdf/2023/June/MS_IJBPAS_2023_6926.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.6.6926