Alstonia scholaris (L.) R. Br. is medicinal plant species (Family: Apocynaceae). A.
scholaris has several drug applications for the treatment of various chronic diseases and
it has limited information regarding its traditional use in treating diabetes from a
scientific perspective. To determine the phytochemical compositions of three different
extracts of A. scholaris; chloroform extract (CEAS), ethyl acetate extract (EAEAS), and
ethanolic extract (EEAS) of A. scholaris leave. In addition, we evaluated the effects of
these three extracts on glucose homeostasis in normal rats using the oral glucose
tolerance test (OGTT). Male Wistar rats (250-300 g) were randomly divided into twelve
groups (n=3/group). Normal saline-treated group, three different doses of all the three
extracts (200, 400, 800 mg/kg, p.o.) treated groups, canagliflozin (CANA) 1mg/kg, p.o
treated group, and metformin (MET) 200 mg/kg, p.o standard treated group. After 30
minutes of drug administration, all groups were given a glucose solution (2g/kg). At 0,
30, 60, 90, 120, and 150 minutes, blood glucose levels were measured by pricking tail
veins with a glucometer. The phytochemical screening of the crude extract revealed the
presence of alkaloids, flavonoids, terpenoids, phenols, and saponins. At doses of 400
mg/kg, EAEAS and EEAS significantly reduced blood glucose levels (p<0.05) compared
to the vehicle control and the standard drugs. However, CEAS did not show any significant changes compared to vehicle control at any dose. EAEAS and EEAS at
400mg/kg dose have phytochemical constituents that improve the anti-hyperglycemic
effect and maintain glucose homeostasis in hyperglycemia.
Keywords: Alstonia scholaris, Anti-hyperglycemic, Diabetes, Glucose Homeostasis,
Oral Glucose Tolerance Test (OGTT)
Publication date: 01/05/2023
https://ijbpas.com/pdf/2023/May/MS_IJBPAS_2023_71121.pdf
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https://doi.org/10.31032/IJBPAS/2023/12.5.7112
