ABSTRACT

Diabetes mellitus is one of the main problems that healthcare systems are now confronting. Diabetes patients may have a variety of issues, including diabetic foot ulcers. A common consequence of diabetes is diabetic foot ulcers. The complexity of diabetic mellitus has increased during the past several decades. According to study, diabetic foot ulcers are the most frequent reason for hospitalisation for diabetics. All forms of gangrene are brought on by a decrease in blood flow to a specific area. A few typical causes of gangrene include vascular problems, burns, Raynaud's syndrome, diabetes, injuries, immune system deficiencies, etc. The four elements of the diabetic gangrene pathogenesis are as follows Vascular, Neuropathy, Infection, and Delayed Wound Healing. The broad etiologies, pathophysiology, investigation, and treatment of diabetic gangrene are briefly reviewed in this paper. Additionally, we highlighted rodent models of diabetic gangrene like arachidonic acid-induced hind limb gangrene and reliable mouse model of hindlimb gangrene. Keyword: Diabetes Mellitus, Diabetic foot ulcer, Animal Model
Publication date: 01/05/2023

https://ijbpas.com/pdf/2023/May/MS_IJBPAS_2023_7170.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.5.7170