ABSTRACT

Thyroid hormone has an effect practically on every tissue and organ system in the body. Iodine absorption is as essential in the body as TSH balance and the persistent imbalance in iodine with TSH causes an increased risk of disorders. Deficiency of iodine and abnormal serum TSH results in hypothyroidism and hyperthyroidism. Hypothyroidism is a common clinical and pathological condition which arises from the deficiency of thyroid hormones produced insufficiently by thyroid gland. Several animal models of hypothyroidism are performed to determine the pathophysiological conditions and level of thyroid hormones in blood. The main objective of this article is to explain the details of hypothyroidism including pathophysiology, signs and symptoms, diagnosis and different principles of different experimental animal models and the main focus is on methods to induce hypothyroidism using laboratory animals. Keywords: Hypothyroidism, Triiodothyronine, Carbimazole, Drug induced hypothyroidism
Publication date: 01/05/2023

https://ijbpas.com/pdf/2023/May/MS_IJBPAS_2023_7163.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.5.7163