ABSTRACT

Cancer is the second largest cause of death in worldwide and its incidence continues to increase. Approximately 12 million people get newly diagnosed of cancer every year, and will increase to around 25 million in year 2030. There are several treatment modalities available to cure different types of cancers which include surgery, radiation therapy, chemotherapy, biological therapy and hormone therapy. Amongst them chemotherapy involving the use of cytostatic or cytotoxic agents remains the mainstay of treatment. However, the major obstacle that limits the effective use of chemotherapy is toxic effects induced by the chemotherapeutic agents. Natural products have been used worldwide as traditional medicines for thousands of years to treat various forms of diseases including cancer. Polyphenolic agents are plant metabolites widely spread throughout the plant kingdom. Phenolic acids have shown the potential as effective agents for cancer prevention and treatment through several mechanisms. This article is a compilation of information available on several databases such as PubMed, Directory of Open Access Journals (DOAJ), Elsevier- Sciencedirect, Google Scholar, Springerlink, Taylor & Francis etc. regarding the role of polyphenols in the mitigation and treatment of cancer through several mechanistic pathways as well their protective effect against the cancer chemotherapy induced toxicities. Keywords: Cancer; Chemopreventive; Chemoprotective; Chemotherapy; Polyphenols
Publication date: 01/05/2023

https://ijbpas.com/pdf/2023/May/MS_IJBPAS_2023_71011.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.5.7101