AN OVERVIEW OF ANIMAL MODEL OF INFLAMMATORY BOWEL DISEASE Authors: Patel R* And Kakadiya J
ABSTRACT
Inflammatory Bowel Disease (IBD) is a general word that refers to a variety of disorders
caused by chronic gastrointestinal inflammation. Ulcerative colitis and Crohn's disease are
the two most serious inflammatory bowel diseases. In Crohn's disease, inflammation disturbs
the whole digestive tract, while ulcerative colitis affects only the large intestine (also known
as the colon. Both illnesses were caused by an impaired immune system response. Which
have common symptoms and cause digestive problems and inflammation in the
gastrointestinal tract. Although the basic etiology of IBD is unknown, there are several
factors that may contribute to the pathogenesis of this disease, such as dysregulation of
immune system or commensal bacteria, oxidative stress and inflammatory mediators. In order
to understand these different etiological factors, a number of experimental models are
available in the scientific research, including chemical-induced, spontaneous, genetically
engineered and transgenic models. In recent decades, various IBD animal models have been
produced. IBD animal models are important and invaluable instruments for studying the role
of various factors in the pathogenesis of IBD and evaluating various therapeutic options. The
current review focuses on the introduction of IBD and drug- induced IBD and the
mechanisms that cause Croh’s disease and ulcerative colitis, as well as the clinical situation.
Keywords: Inflammatory Bowel Disease, Pathophysiology, DSS Publication date: 01/05/2023 https://ijbpas.com/pdf/2023/May/MS_IJBPAS_2023_7153.pdfDownload PDFhttps://doi.org/10.31032/IJBPAS/2023/12.5.7153
