ABSTRACT

Aim of the study was to find out the potential of HPMC-based polymeric matrices formulation such as carriers for gastrointestinal tract targeted drug therapy of verapamil hydrochloride capsule formulation. Prepared single-unit hydrodynamically balanced (HBS) capsule formulations by the encapsulation using hard gelatin capsules technique properly mix all the physical mixtures of various drug polymers such as HPMC, K4M and Carboxymethyl Chitosan. At the time of In-vitro study in 0.1M HCL shows good floating time (5-10 hr) and drug release profile were carried out using 0.1M HCL as a dissolution medium. Finally prepared HPMC- based polymeric matrices formulation was very helpful for gastrointestinal tract delivery. Keywords: Carboxy-methyl Chitosan, HPMC K4M, Verapamil Hydrochloride, Hydrodynamic Balance System
Publication date: 01/05/2023

https://ijbpas.com/pdf/2023/May/MS_IJBPAS_2023_7150.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.5.7150