ABSTRACT

The main goal of this research is to estimate and validate the concentrations of Famotidine and Domperidone in bulk and marketed formulations. Famotidine belongs to the H2 blocker family. It is used to protect you and treat heartburn. Domperidone is a dopamine receptor antagonist used to treat dyspepsia, nausea, and anti-emetic symptoms. The stationary phase used was Shimadzu column, while the mobile phase was methanol: 0.1% Trifluroacetic acid in water: acetonitrile in the ratio 30:40:30 v/v, with a flow rate of 0.8 ml/min. The injection volume was 10?l, and the detection wavelength was 280 nm. According to ICH Q2 (R1) recommendations, system suitability, specificity, linearity, accuracy, precision, limit of detection, limit of quantification, and robustness were all tested. The linearity of famotidine and domperidone was determined to be 4-20?g/mL and 2-10?g/mL, respectively, with correlation values of 0.9993 and 0.9993. It is a simple, precise, accurate, cost- effective, and robust method and hence used for routine analysis. Key words: Famotidine, domperidone, RP-HPLC, ICH
Publication date: 01/05/2023

https://ijbpas.com/pdf/2023/May/MS_IJBPAS_2023_7124.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.5.7124