ABSTRACT

The purpose of the present research was to formulate and evaluate patient-friendly fast dissolving tablets of lacidipine solid dispersion using direct compression method so as to achieve faster drug dissolution. In the current investigation, an attempt was done to initiate the rapid release of lacidipine from oral tablet dosage formulations through change of drug into solid dispersion form by solvent evaporation method using carriers in different proportions with subsequent formulation of optimum lacidipine solid dispersions into fast dissolving tablets by direct compression method using superdisintegrants. The developed lacidipine solid dispersions were evaluated for percentage practical yield and in-vitro drug release. Fast dissolving tablets of lacidipine solid dispersion were further analysed for pre-compression as well as post-compression characteristics. Depending upon the results obtained for in vitro drug release studies, it was found that the formulation F3 & F9 showed faster drug release profile of about 99.51% in 30 min & 99.51% in 30 min and disintegration time 40 sec & 40 sec, respectively compared to other developed formulations. The preliminary dissolution rate was found to be 34.25% / 10 min & 34.25% / 10 min, respectively for the best formulations F3 and F9. FT-IR graphs showed that there was no interaction between drug & excipients in the formulations. The present investigation explored the possibility for the faster dissolution of lacidipine solid dispersion based fast dissolving tablets developed by direct compression technique. Keywords: Lacidipine, solid dispersion, fast dissolving tablets, superdisintegrant, % practical yield, in vitro drug release
Publication date: 01/05/2023

https://ijbpas.com/pdf/2023/May/MS_IJBPAS_2023_7109.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.5.7109