ABSTRACT

Oral drug delivery is one of the most commonroute of drug administration due to its patient compliance and ease of usage. But this route is an immense challenge for the drug delivery to the pediatric patients. Our present research work emphasizes on the solution to this problem. The present research work deals with the formulation and evaluation of a medicated chocolate of ondansetron, which is one of the most common medicines used for pediatrics for the treatment of emesis. Chocolate is a range of products derived from cocoa which is mixed with cocoa butter and finely powdered sugar to produce a solid confectionery. Chocolates were formulated (F1-F6) with cocoa powder, cocoa butter, soya lecithin, sucrose and milk powder. The created chocolate formulas were put to the test in terms of general appearance, hardness, melting point, dimension, moisture content, weight variation, drug content, In vitro drug release, moisture content, blooming test and stability test. Within 60 minutes, the F1 formulation releases the entire medication. The results show that the formulation has no drug-excipient interactions and that the drug has not degraded throughout the manufacture of the chocolate formulation. Keywords: Ondansetron, Medicated chocolate, Pediatrics, In vitro drug release
Publication date: 01/05/2023

https://ijbpas.com/pdf/2023/May/MS_IJBPAS_2023_7094.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.5.7094