ABSTRACT

Recently in the field of oral drug delivery, the Gastro retentive Drug Delivery system (GRDDS) has gained immense popularity. By this systems dosage form retain in the stomach for an extended period and release the drug slowly that can challenge may disadvantage associated with conventional oral delivery, including poor bioavailability. Such dosage forms aim to release drugs in the upper part of the gastrointestinal tract especially in the stomach in a controlled release manner that might provide sustained release characteristics without sacrificing much of total bioavailability. Apart from in vitro characterisation, successful GRDDS development demands well designed in vivo study to establish enhanced gastro retention and prolonged drug release. Gamma scintigraphy and MRI are popular techniques used to evaluate in vivo gastric residence time. The floating drug delivery systems are required to possess the proper floating capability in gastric systems and the use of natural polymers in such a delivery system has been very beneficial. Natural gums are among the most popular hydrophilic polymers be because of cost-effectiveness and regulatory acceptance. Natural polymers have no. of advantages like nontoxic, biocompatible, natural in origin. This review also gives a brief idea about advanced polymers including Eudragit, Carbopol, Hydroxyl Propyl Methyl Cellulose etc. and other excipients used for formulating GRDDS. This review also highlights the different in vivo evaluation parameters of GRDDS. Keywords: Applications, Gastro Retention, Invivo and Invitro Methods, Polymer Swelling
Publication date: 01/05/2023

https://ijbpas.com/pdf/2023/May/MS_IJBPAS_2023_7072.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.5.7072