ABSTRACT

Most of the synthetic and natural compounds contain Benzothiazole nucleus that have various pharmacological activities like Anti-microbial Anti-parasitic, anti-bacterial, anti-fungal, antioxidant, anti-tubercular, antineoplastic, antiviral, anti-inflammatory, and so on. Microbial infections are the most widespread and dangerous infections in the world, caused by various viable pathogens. Hence, due to the rise of microbial infections, and widespread use of benzothiazole, the study is an attempt to identify a better anti-microbial agent through in silico studies. The binding energies of benzothiazole bearing chloro and nitro substitutions were to be -7.87 and -7.72 against the protein with PDB ID 2EG7. These two compounds were synthesised and evaluated for in vitro anti-microbial activity. Keywords: - Benzothiazole, Anti-microbial activity, Docking, ADME, Toxicity
Publication date: 01/04/2023

https://ijbpas.com/pdf/2023/April/MS_IJBPAS_2023_7055.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.4.7055