ABSTRACT

Background: Pregabalin is a structural analogue of gamma-amino butyric acid (GABA), which act as inhibitory neurotransmitters of brain having a strong affinity to the ?2 subunit of pre-synaptic voltage – gated calcium channel receptor to decrease post synaptic excitatory neurotransmitter release. This binding of pregabalin leads to its anxiolytic, anticonvulsant and antinociceptive effects. The efficacy of pregabalin in acute postsurgical pain has been demonstrated in numerous studies; however, the analgesic efficacy and adverse effects of using pregabalin in various surgical procedures remain uncertain. Data Sources: The literature for the study was collected from January 2010 to November 2018, using PubMed, Google scholar, NCBI and Clinical Trials.gov with no limitation on publication year or language. Studies considered for inclusion were randomized controlled trials with treatment of perioperative pregabalin. Therefore the present study was focused in the assessment of postsurgical analgesic efficacy after pregabalin administration under different spine surgical categories using appraised research studies. Conclusion: Upon reviewing various literatures, we uphold the preferential use of pregabalin over gabapentin based on its superior pharmacokinetics and pharmacodynamics. Keywords: Pregabalin, Neuropathic pain, Postoperative pain, Spine surgeries, Gabapentin
Publication date: 01/04/2023

https://ijbpas.com/pdf/2023/April/MS_IJBPAS_2023_7051.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.4.7051