ABSTRACT

The intranasal route of drug delivery is reliable in so many ways. This route of drug delivery not only has less side-effect compared to other dosage forms but also has more bioavailability. There is no degradation of drug by enzymes as in case of oral route. It offers better patient comfort and preference as it is needleless and pain free which can aslo be favourable in case of diseases that require long term treatment. Lipophilic drugs can be administered via transcellular aided route. This route is preferable for local as well as systemic delivery of drug. The distribution of dose is enhanced and has a possibility of crossing the blood brain barrier (BBB) which is beneficial for treatment of CNS disorders. This route has a significant potential to deliver various therapeutic substances like small molecules, large molecules, lipophilic drugs, and stem cells to the brain. Keywords: Intranasal route, bioavailability, lipophilic, transcellular, enzymes, local, systemic
Publication date: 01/04/2023

https://ijbpas.com/pdf/2023/April/MS_IJBPAS_2023_7022.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.4.7022