ABSTRACT

Neurogenetic disorders are few diseases that bring depression and Muscular restrictions into the human body. One such Disease is Charcot-Marie-Tooth (CMT) disease which is due to the alterations of the Peripheral Myelin Protein (PMP) gene in the Peripheral Nervous System. Recent researches have revealed that it might also be due to hypomyelination and decreased dopamine levels in the Peripheral Nervous system. Since L-Dopa is already used for Parkinson’s disease (PD) to regulate dopamine levels, an in-silico investigation is done to recognize L-Dopa for CMT disease as well. This research work is about molecular docking of L-Dopa with PMP to identify the binding affinity and investigate the binding properties so that it can be used in CMT affected persons to decline stress levels. The initial phase of our research work is to dock L-Dopa with ASN and further to dock L-Dopa with PMP. Our docking study results revealed 2 hydrogen bonds for ASN and 6 hydrogen bonds for PMP. Hence, Increasing dopamine will have an impact on reducing stress and depression caused due to CMT. Keywords: Charcot-Marie Tooth (CMT) disease, L-Dopa, Neuro-genetic disorder, Peripheral Myelin Protein (PMP)
Publication date: 01/04/2023

https://ijbpas.com/pdf/2023/April/MS_IJBPAS_2023_7007.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.4.7007