ABSTRACT

Reproductive effects from herbicide exposure in mammals and the ecological assessment of chronic exposure is currently seen to be matter of concern. Quizalofop-p-ethyl is a herbicide used for controlling grass weeds in various crops such as soybeans, peanuts, cotton, potatoes, sugar beets and flax. The general toxicity of herbicide is well studied but reproductive toxicity studies are lacking. So an attempt has been done to assess the male reproductive toxicity. The LD50 of Quizalofop-p-ethyl in mice is 2350 mg/kg. Male mice were given oral doses of 1/25th of LD50 of the Quizalofop-p-ethyl (587.5 mg/kg) and 1/50th LD50 (1175 mg/kg) dissolved in water for 30 and 60 days respectively. Symptomatic behavioural changes were noticed, body weight and food consumption was decreased gradually. Treated mice group at 60 days showed significant decrease in testis, epididymis and seminal vesicle weight as compared to group which was given 30 days treatment. The biochemical analysis shows significant decrease in protein, fructose and sialic acid values at both doses levels 587.5mg/kg and 1175mg/kg for 30 and 60 days, increase in cholesterol and glycogen level has been seen at both days of treatment. The male reproductive toxicity of Quizalofop-p-ethyl suggests the restricted use of herbicide in public places. Keywords: Quizalofop-p-ethyl, Biochemical analysis, reproductive toxicity, male swiss albino mice
Publication date: 01/03/2023

https://ijbpas.com/pdf/2023/March/MS_IJBPAS_2023_6986.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.3.6986