ABSTRACT

Objective: This research work deals with the design and development of the solid lipid nanoparticles to improve solubility of poorly soluble drug of olmesartan. Methods: Olmesartan solid lipid nanoparticles are formed using hot homogenization technique followed by ultrasonication technique. Experiment trend is predicted using the standard calibration curve. Sample analysis is done by scanning electron microscopy (SEM). Parameters measured are zeta potential, entrapment efficiency, and the in-vitro drug release. Results: The parameters studied are the percent drug release, entrapment efficiency, particle size of SLN and the in-vitro drug release of prepared SLN Conclusion: The results obtained in this research work clearly indicated that the developed solid lipid nanoparticle delivery system for the highly lipophilic drug, olmesartan using stearic acid, glyceryl monostearate as carrier matrices can be used effectively for hypertension. Keywords: Entrapment efficiency, Hot homogenization technique, Hypertension, Olmesartan, invitro drug release, Scanning electron microscopy (SEM), Solid Lipid Nanoparticles (SLN), Ultrasonication technique, zeta potential
Publication date: 01/03/2023

https://ijbpas.com/pdf/2023/March/MS_IJBPAS_2023_6961.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.3.6961