ABSTRACT

N, N’ disubstituted acyl thioureas are of crucial importance due to their wide range of biological activities such as antiinfluenza, antifungal, antibacterial and anti-inflammatory, etc. Six disubstituted acyl thioureas, say N’-(3-nitrobenzoyl)-N-(4-fluorophenyl)thiourea (I), N’-(3, 5-dinitrobenzoyl)-N- (benzyl)thiourea (II), N’-(4-methoxybenzoyl)-N-(4-fluorophenyl)thiourea (III), N’-(3,5- dinitrobenzoyl)-N-(3-hydroxyphenyl)thiourea (IV), N’-(4-methoxybenzoyl)-N-(3- hydroxyphenyl)thiourea(V) and N’-(4-nitrobenzoyl)-N-(3-hydroxyphenyl)thiourea (VI) have been synthesized and characterized by spectral analyses. Synthesized compounds were screened for their antimicrobial activity against Staphylococcus aureus, Candida albicans and Enterococcus faecalis by Minimum Inhibitory Concentration (MIC) method. Among the synthesized compounds, N’-(3,5- dinitrobenzoyl)-N-(3-hydroxyphenyl)thiourea (IV) was found to be as comparable to that of the Minimum Inhibitory Concentration of 2?g/ml and 1?g/ml against Staphylococcus aureus and Candida albicans as compared to standard amikacin and nystatin, respectively, while compound N’-(4- methoxybenzoyl)-N-(3-hydroxyphenyl)thiourea(V) was found effective against Enterococcus faecalis at the minimum inhibitory concentration of 31.25 ?g/ml.
Publication date: 01/03/2023

https://ijbpas.com/pdf/2023/March/MS_IJBPAS_2023_6952.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.3.6952