ABSTRACT

Any drug delivery technique must deliver a therapeutic dose of medicine to the desired location in the body while also maintaining an effective plasma drug concentration for a certain time period. Incomplete drug release results in a shorter duration of action of the dose form and a decreased bioavailability of the medication. A gastro retention medication delivery device is employed to circumvent this issue. The point of this study is to look at the various medication delivery techniques for gastro-retention that have been utilized to increase the therapeutic effect of pharmaceuticals with a short therapeutic window, are unsteady at basic pH, are soluble in acidic medium, and are active locally in the stomach. The anatomy of the stomach, the factors affecting GRDDS, and the various GRDDS techniques currently used in gastric retention drug delivery systems, such as hydrodynamically balanced systems, super porous hydrogel systems, magnetic systems, muco-adhesive systems, high-density, low-density systems and micro balloon systems are discussed in detail, along with their applications and advantages. Additionally, it considers prospective approaches for increasing stomach retention duration in fasting and fed states. In summary, this research sheds light on existing and future perspectives on gastric retention medication delivery systems. Keywords: Effervescent system, FDDs, GRDDs, HBS, Stomach
Publication date: 01/03/2023

https://ijbpas.com/pdf/2023/March/MS_IJBPAS_2023_6948.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.3.6948