ABSTRACT

For thousands of years, nasal drug delivery has been practiced and has brought a new lease on life. Nose cavity were considered as complementary path for systemic accessibility of medicament those have limitation to administer it intravenously. This is because of porous endothelial membrane, elevated blood flow, greater surface area, more penetration of certain medicaments in the nose membrane, and ameliorates the patient's compliance with the quick absorption of medicaments via this membrane. Also it confers quick onset of action, enhanced patient acceptance and satisfaction, sustained activity when correlate with various system of drug delivery. In a nasal drug delivery system, formulations such as nasal gel achieved recent attention in a pharmaceutical domain possess multitudinous effects of other nasal formulations like solids, liquids and sprays. The formulations of nasal gel are easy to prepare, more apparently acceptable as it offers quick onset of action, avoids first pass metabolism, minimum risk of side effects, elevated residence time, and enhanced patient compliance. This review sets out to discuss benefits, drawbacks, method of preparation, different additives used in nasal gel and evaluation parameters of nasal gel. Keywords: Bioavailability, first pass metabolism, nasal gel, evaluation, etc
Publication date: 01/03/2023

https://ijbpas.com/pdf/2023/March/MS_IJBPAS_2023_6936.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.3.6936